rhein相关论文
Objective :To study Carboxymethyl Chitosan-Rhein conjugate(CR conjugate)effects intestinal absorption of Paclitaxel(PTX)......
Preparation and Evaluation of Rhein-loaded PEG-PCL-PEI Nanoparticles on Streptozotocin-induced Nephr
Rhein(RH,4,5-dihydroxyanthraquinone-2-carboxylic acid),an anthraquinone derivative extracted and separated from Rheum pa......
In vitro/in vivo ihvestigation of metabolic drug-drug interaction of Rhein through CYP inhibition st
Aim To investigate the metabolic drug-drug interaction (DDI) potential of rhein through CYP450.Methods Specific substrat......
Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57BL/6 mouse through t
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine.However, th......
Aim: Rhein (4,5-dihydroxyanthraquinone-2-carboxylicacid; 1,8-dihydroxy-3-carboxyanthraquinone) is a major constituent in......
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Pharmacokinetic behavior of argirein,a super molecule derived from rhein,is characterized as slow re
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Activation of AQP4,p66Shc and ER stress chaperone involved in carrageenin induced acute inflammation
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Determination of Anthraquinones in Craniocerebral Injuries Patient after Oral Administration of Rhub
Objective To determinate the anthraquinones in plasma of patient with craniocerebral injuries after Rhubarb administrati......
Syntheses and properties of cyclometalated complexes with modified natural product ligand as potenti
Cancer has become the top killer to human lives.Recently,transition metal based complexes with unique biochemical proper......
Rhein inhibits transforming growth factor β1 induced plasminogen activator inhibitor-1 in endothelia
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目的建立同时测定桃核承气汤中苦杏仁苷、肉桂酸、大黄酸、大黄素、甘草酸含量的超高效液相色谱-串联质谱（ultra performance liqui......
目的建立润肠丸中大黄酸成分的高效液相色谱测定方法。方法：Phenomenex Luna C18柱(5um，150x4.60mm，100A)；流动相：乙腈-0.1%磷酸(60：40)；......
目的:采用Box-Behnken响应面法对小承气汤煎煮条件进行优化。方法:以大黄酸、芦荟大黄素和辛弗林为评价指标,进行了药液比、煎煮次......
目的：建立通腑脐贴膏的质量控制方法。方法采用薄层色谱法对通腑脐贴膏中的大黄、厚朴、枳壳进行定性鉴别，采用高效液相色谱法测定制......
目的用HPLC法同时测定消氮颗粒中芦荟大黄素、大黄酸、大黄素、大黄酚和大黄素甲醚5种成分的含量。方法选用VP-ODS C18色谱柱(250 ......
目的制定炎黄保肾胶囊的质量控制方法。方法采用HPLC法测定炎黄保肾胶囊中大黄酸、大黄素、大黄酚的含量,并制定含量限度。结果 HP......
目的:优选加味血肿解复方的提取工艺。方法:采用小肠推进动力学试验比较水煎煮法和水蒸气蒸馏法对加味血肿解复方药效的影响;以大......
大黄酸,化学结构式为1,8-二羟基-3-羧基蒽醌,是富含于大黄根茎中的一种蒽醌类化合物,已经被证实具有抗炎与抗氧化的作用.最近研究......
目的研究桃核承气汤中蒽醌类成分在大鼠体内药代动力学规律.方法大鼠灌胃给予桃核承气汤5、10 g.kg-1后,采集血浆、尿和胆汁,用HPL......
目的建立HPLC同时测定黄石感冒片中阿魏酸、芦丁、大黄酸、大黄素和大黄酚的含量。方法采用HPLC,色谱柱为Welch Topsil-C18柱(4.6 ......
Protective effects of catalpol and rhein in murine experimental au-toimmune encephalomyelitis via re
OBJECTIVE: To examine the effects of catalpol and rhein on pro-and anti-inflammatory responses in C57BL/6 mice with expe......
,Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothe
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目的:探讨大黄酸和吡格列酮各自对高脂诱建的大鼠非酒精性脂肪性肝炎(NASH)的影响及其可能的机制.方法:52只清洁级雄性SD大鼠,体重......
目的探讨高效液相色谱(HPLC)测定载大黄酸的空腔碳酸钙(Ca CO3)纳米球血药浓度,以评价其在大鼠体内缓释效果。方法采用HPLC法测定......
目的研究大黄酸对镉致雄性大鼠生殖毒性的干预作用。方法雄性SD大鼠32只,随机分为四组,分别为空白对照组、染镉组、大黄酸低剂量组......
Rhein inhibits transforming growth factor β1 induced plasminogen activator inhibitor-1 in endothelia
Objectives To investigate the effect of rhein on endothelial plasminogen activator inhibitor-1 (PAI-1) mRNA expression ......
Background 5-dihydroxyanthraquinone-2-carboxylic acid (rhein) inhibits oxidoreduction induced by reducing nicotingamide ......
目的 探讨c-kit在蒽醌类泻剂所致肠动力减退发病机制中的作用.方法 健康成年SPF级SD大鼠36只随机均分为模型组、模型恢复组和对照......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
改善胰岛素敏感性对防治2型糖尿病(T2DM)有重要意义.我国中医药治疗糖尿病效果显著但机制尚不甚清楚,本课题组从改善胰岛素敏感性......
Rhein inhibits transforming growth factor β1 induced plasminogen activator inhibitor-1 in endothelia
Objectives To investigate the effect of rhein on endothelial plasminogen activator inhibitor-1 (PAI-1) mRNA expression a......
Background 5-dihydroxyanthraquinone-2-carboxylic acid (rhein) inhibits oxidoreduction induced by reducing nicotingamide ......
目的 观察何首乌对人正常肝细胞的毒性和细胞凋亡的影响,探讨何首乌致肝损伤的可能物质和途径.方法 以人正常肝(实质)细胞系L02为......
目的：建立以HPLC法测定上清丸中大黄酸、大黄素、大黄酚含量的方法。方法：采用Symmetry C18柱，以甲醇-0．1％磷酸＝80：20为流动相，检测波长：430......
目的:研究大黄酸对人胰腺癌细胞增殖和迁移的影响,并探讨其作用机制。方法:用不同浓度的大黄酸处理人胰腺癌MiaPaCa-2细胞,CCK8法......
目的:探讨脂肪相关基因(fat mass and obesity associated gene,FTO)及其抑制剂大黄酸(rhein)在非酒精性脂肪肝病(non-alcoholic f......
以大黄酸为原料,利用其羧基通过不同的连接臂与呋咱氮氧化合物偶联,得到7个NO供体型大黄酸衍生物,其结构经红外光谱、核磁共振氢谱......
目的：建立HPLC法测定大败毒胶囊中大黄素的含量.方法：色谱柱为Phenomenex ODS C18柱,流动相为甲醇-0.4%醋酸液（85：15）,检测波长438nm,流......
目的观察大黄酸对人工动情期大鼠离体子宫平滑肌条的作用及探讨其作用机制。方法将子宫平滑肌条悬挂于离体平滑肌灌流肌槽装置内，采......
目的:建立测定通便宁胶囊中大黄酸含量的高效液相色谱法。方法:采用KromassilC18(5μm,250mm×4.6mm),以甲醇—0.1%磷酸溶液(8......
AIM: To investigate the effects of rhein on intestinal epithelial tight junction proteins in rats with IgA nephropathy (......
目的:测定生发灵酊(当归、红花、何首乌等)中阿魏酸和大黄酸的含量.方法:高效毛细管电泳法.毛细管(60cm×75μm,有效长度53cm)......
目的测定大鼠灌服凉血通瘀方后血清中大黄酸的浓度。方法采用HPLC法测定大鼠含药血清中大黄酸的浓度,血清样品经H_2SO_4溶液酸化后......
目的评价大黄酸对便秘模型小鼠胃肠蠕动功能的影响。方法用复方地芬诺脂制造小鼠便秘模型,大黄酸组给予大黄酸,记录6 h内的首次排......
目的:建立用HPLC(高效液相色谱)同时测定虎杖中大黄素、大黄酸、大黄酚、大黄素甲醚含量的方法.方法:用超声波提取;C8色谱柱5μm,1......
大黄素、大黄酸、大黄酚对胰蛋白酶活性均有一定程度的抑制作用．当有效成分浓度为2．5mg·L^-1时，长濑法测定表明它们对胰蛋白酶的......
采用正交试验法,以大黄酸及醇提干浸膏得率为观察指标,对伤速康涂膜剂的提取工艺进行了实验研究.对大黄酸提取率、干浸膏得率影响......
目的：建立新三黄合荆的质量标准。方法：用TLC法对大黄、丹参、姜黄、水蛭进行定性鉴别；用HPLC法测定大黄中大黄酸、大黄素和大黄酚的......
目的建立胃痛欣颗粒剂中大黄酸、大黄素、大黄酚的含量测定方法.方法采用高效液相色谱法,Accusil C18(4.6 mm×250 mm,10 μm)......
